Korean J healthc assoc Infect Control Prev 2024; 29(1): 19-26
Published online June 30, 2024 https://doi.org/10.14192/kjicp.2024.29.1.19
Copyright © Korean Society for Healthcare-associated infection Control and Prevention
Department of Laboratory Medicine, Kyung Hee University Hospital, Kyung Hee University College of Medicine1, Department of Laboratory Medicine, Korea University Guro Hospital, Korea University College of Medicine2, Seoul, Korea
Correspondence to: Min-Chul Cho
E-mail: minchulcho7397@gmail.com
ORCID: https://orcid.org/0000-0002-0609-7734
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).
Urinary tract infection (UTI) is a common and costly disease that affects millions of people worldwide each year. Accurate laboratory diagnosis of UTI is crucial to reduce antimicrobial resistance in UTI pathogens because of unnecessary antimicrobial use. Routine urinalysis with urine dipstick analysis and Gram staining can be used to screen for UTI. The conventional ‘gold standard’ for diagnosing UTIs involves culture-based tests. This method entails culturing the urine sample to amplify the bacteria to detectable levels, followed by biochemical and serological tests, as well as antimicrobial susceptibility tests. However, culture-based tests have the disadvantage of requiring 48-72 hours to report results owing to the time needed for bacterial growth. Therefore, various methods have been developed and are used to diagnose UTI to replace time-consuming culture tests. These methods include flow cytometry, mass spectrometry, and nucleic-acid-based diagnostic tests. This review introduces various laboratory methods used to diagnose UTI in clinical microbiology laboratories and discusses their principles and interpretation methods.
Keywords: Urinary tract infection, Laboratory diagnosis, Urine culture, Flow cytometry, Molecular diagnostics
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