닫기

대한의료관련감염관리학회

View

Original Article

Korean J healthc assoc Infect Control Prev 2023; 28(1): 113-125

Published online June 30, 2023 https://doi.org/10.14192/kjicp.2023.28.1.113

Copyright © Korean Society for Healthcare-associated infection Control and Prevention

Chechk for updates

Epidemiology of Catheter-related Bloodstream Infections in Neonatal Intensive Care Units: A Rapid Systematic Literature Review

Erdenetuya Bolormaa1*, Choryok Kang2*, Young June Choe3,4 , Joo Seon Heo3,5, Hannah Cho3

Department of Preventive Medicine, Korea University College of Medicine1, College of Nursing, Seoul National University2, Department of Pediatrics, Korea University Anam Hospital3, Allergy and Immunology Center, Korea University4, Institute of Nano, Regeneration, Reconstruction, Korea University College of Medicine, Korea University5, Seoul, Korea

Correspondence to: Young June Choe
E-mail: choey@korea.ac.kr
ORCID: https://orcid.org/0000-0003-2733-0715

*Equally contributed to the manuscript.

Received: March 15, 2023; Revised: April 28, 2023; Accepted: May 8, 2023

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).

Abstract

Background: Catheter-related bloodstream infections (CRBSIs) are serious complications in neonatal intensive care units (NICUs). We aimed to assess the incidence of CRBSIs in NICUs worldwide and describe the causative organisms.
Methods: We searched PubMed, EMBASE, Cochrane, and KoreaMed databases. We included studies on CRBSIs in NICU settings with data on bacteremia. We performed a random-effects meta-analysis on CRBSI incidence in NICUs, stratified the data according to WHO regions. We compiled data on underlying organisms.
Results: Of the 692 studies identified, 71 published between 2011 and 2022 were considered eligible. The pooled incidence of CRBSI per 1000 catheter days in NICUs was 8.66 (95% confidence interval [CI], 7.19; 10.12). Stratifying by WHO regions, the CRBSI incidence per 1000 catheter days was 10.38 (95% CI, 3.86; 16.90) in the Eastern Mediterranean Region (EMR), 11.77 (95% CI, 9.20; 14.35) in the European Union Region (EUR), 5.94 (95% CI, 3.87; 8.00) in the Western Pacific Region (WPR), and 6.71 (95% CI, 4.39; 9.03) in the Region from the Americas (AMR). Of the 2887 bacterial strains, 73.4% (n=2118) were gram-positive bacteria, 18.9% (n=547) were gram-negative bacteria, and 7.8% (n=225) were fungi. Coagulasenegative Staphylococci (n=1380, 65.2%) were the most common pathogen among the grampositive types, followed by Staphylococcus aureus (n=318, 15%). Among the CRBSI gramnegative cultures, Klebsiella spp. (n=201, 36.7%) was the primary pathogen.
Conclusion: We found a substantial burden of CRBSIs in NICUs across the globe. Our findings highlight the need to improve the implementation of global and local strategies to reduce CRBSIs in NICUs.

Keywords: Neonate, Bacteremia, Catheters, Infection control, Systematic review

Share this article on :

Related articles in KJICP

더보기

Analysis of Characteristics and Prognosis of Healthcare-Associated Secondary Bloodstream Infection

Song Yi An, Woong Jung, Chang Min Lee, Sung Hyuk Park, Hyun Kyung Park, Myung Chun...

2017; 22(2): 43-55 https://doi.org/10.14192/kjicp.2017.22.2.43

Impact of Active Surveillance for Carbapenem-resistant Enterobacterales in a Homeless Patient Ward

Song Yi An, Woong Jung, Chang Min Lee, Sung Hyuk Park, Hyun Kyung Park, Myung Chun...

2024; 29(2): 128-136 https://doi.org/10.14192/kjicp.2024.29.2.128

Management of Sink in the Healthcare Facility to Prevent the Spread of Gram-negative Organisms

Song Yi An, Woong Jung, Chang Min Lee, Sung Hyuk Park, Hyun Kyung Park, Myung Chun...

2024; 29(2): 103-109 https://doi.org/10.14192/kjicp.2024.29.2.103

Most KeyWord