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Korean J healthc assoc Infect Control Prev 2021; 26(2): 96-100

Published online December 31, 2021 https://doi.org/10.14192/kjicp.2021.26.2.96

Copyright © Korean Society for Healthcare-associated infection Control and Prevention

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Predictive Value of Positive Interferon-Gamma Release Assay for Hemodialysis Patients: A Cross-Sectional Study in a Tertiary Care Hospital in South Korea

Ye Na Kim, Jinyoung Lee, Yeonsoon Jung

Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea

Correspondence to: Yeonsoon Jung
E-mail: kidney@hanmail.net
ORCID: https://orcid.org/0000-0003-3657-7082

Received: November 6, 2020; Revised: March 5, 2021; Accepted: March 12, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).

Abstract

Background: Tuberculosis (TB) is a common infectious disease in dialysis patients with profound alterations in immune response. The risk of TB among dialysis patients is important but remains unclear. This study aimed to determine various factors associated with latent TB infection (LTBI) in patients undergoing hemodialysis (HD) in Korea.
Methods: This cross-sectional study was conducted in a tertiary care hospital in South Korea. HD patients were tested with interferon-gamma release assay (IGRA) and filled out a questionnaire for LTBI association factor assessment and analysis. The variables (age, sex, body mass index, smoking, previous contact with a person with active TB, dialysis duration, and hemoglobin and albumin levels) were included in a logistic regression model.
Results: Of the 82 participants enrolled, 45 (54.9%) in the dialysis group were IGRA-positive. Independent predictors of LTBI in patients undergoing HD were age (50-59 years), smoking habit, history of contact with an active TB case, and duration of HD (≥60 months) using multivariate logistic regression.
Conclusion: The prevalence of positive IGRA was >50% among HD patients in a tertiary care hospital in South Korea. Therefore, routine screening tests for LTBI with IGRA in HD in Korea are recommended, especially for patients aged 50-59 years, those who smoke, and those with a history of contact with an active tuberculosis case and long duration of HD (>60 months).

Keywords: Tuberculosis, Infection, Hemodialysis, Interferon-gamma release assay, Prevalence

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