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Korean J healthc assoc Infect Control Prev 2021; 26(2): 70-82

Published online December 31, 2021 https://doi.org/10.14192/kjicp.2021.26.2.70

Copyright © Korean Society for Healthcare-associated infection Control and Prevention

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Current Strategy and Perspective View for Preventing Clostridioides Difficile Infection in Acute Care Facilities

Si-Ho Kim, Yu Mi Wi

Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University, Changwon, Korea

Correspondence to: Yu Mi Wi
E-mail: yrhg95@naver.com
ORCID: https://orcid.org/0000-0003-3625-3328

Received: November 11, 2021; Revised: December 2, 2021; Accepted: December 3, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0).

Abstract

Clostridium difficile is a spore-forming anaerobic gram-positive bacillus. With increasing antibiotic use, changing patient population, and microbiological characteristics of C. difficile, this pathogen has emerged as one of the most challenging pathogens of nosocomial infections. The current important strategies for preventing C. difficile infection (CDI) are patient monitoring, early recognition (prompt and accurate diagnosis accompanied by an appropriate diagnostic algorithm and a CDI surveillance system), blocking transmission (contact isolation, hand washing, environmental disinfection, and cleaning), and controlling risk factors (increasing the appropriateness of antibiotic use through antibiotic stewardship program). In this review, we will reappraise the clinical efficacy and efficiency of each strategy for preventing CDI and introduce promising interventions for CDI prevention.

Keywords: Clostridioides difficile, Contact isolation, Cross infection, Environmental disinfection, Antimicrobial stewardship program

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