Classification of carbapenemase according to Ambler classification
| Ambler classification | Structure of function | Examples | Representative inhibitors |
|---|---|---|---|
| Class A | Serine carbapenemases | KPC, SME, IMI, NMC, GES | CLA, PBA, tazobactam |
| Class B | Metallo-β-lactamases | NDM, VIM, IMP, GIM, SIM, SPM | Metal-chelating agents (EDTA, Dipicolinic acid) |
| Class D | Serine carbapenemases | OXA | CLA, PBA : variable in vitro NaCl |
Abbreviations: CLA, clavulanic acid; PBA, phenylboronic acid; EDTA, ethylene diamine tetra-acetic acid.
Korean J healthc assoc Infect Control Prev 2023;28:42~49 https://doi.org/10.14192/kjicp.2023.28.1.42
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